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Mammals. Mammals and birds. Mammals. Mammals. Mammals with insect vectors.. Mammals with insect vectors. Mammals with insect vectors.
You may not have noticed my point but it becomes progressively rarer for a pathogen to affect different species the less closely related they are. You find a bunch infecting various mammals and only a very rare few viruses which affect different classes (such as flu) though even then they need to mutate and/or cross with different related strains.
Pathogens need to be adapted to their host prior to the host needing to adapt immunity to them. One does not simply walk into a host organism.
Pathogens surviving and thriving within their host is what makes the host sick.Ah, ok I see now you're talking about making two different species both sick. I just find it more pertinent to this scenario that the pathogen wouldn't necessarily "need to be adapted" to a new host in order to live and thrive within it, as they can already have that functionality within disparate species regardless of whether they've seen the new host before.
Also, we might consider invasive species -- maybe it thrives in the new environment, even so much that it outcompetes all the native species which have been there long before the new guy came around. If some bug in that lake got into a human, maybe it would be like "hey it's warm in here and look at all these nutrients, I'm so happy! nom nom nom." Not totally impossible unless their home lake is, say, highly pressurized. In that case I guess they might just explode. Who knows. But you can't just totally discount the possibility of a newly discovered species being pathogenic.