medicinal mushrooms

What do you mean? Seriously, just be patient at read the above.

And Stigmata is absolutely correct, a LOT of antiviral drugs and antibiotics come from fungi. Penicillin being the most famous.
Its really not that suprising to find mushrooms producing biological response modifiers.
 
I think he's from a race of mushrooms that have developed sentience, and he's an ad-bot harbringer of the apocalypse. After we detonate all the subterranean nukes, it will be known as "The Age of The Mushroom Cloud"
 
God damn it, man, what is it with you and mushrooms? :p



You sound almost religious.
 
15357 said:
God damn it, man, what is it with you and mushrooms? :p



You sound almost religious.
Click to expand...

Everyone gets their one and only thread people remember them by. Also this is still cool news to me, I'd love to buy something knowing it could help save me one day. And sweet baby jebus only knows that if theres a cure out there, the US pharmaceutical companies would pay money to kill it and bury it
 
thefiznut said:
Would you prefer I started linking to PubMed studies?
Click to expand...
Well, yes? That was my point. Thanks for doing so.

thefiznut said:
If you're going to mock me and call me liar and a homeopathic quack please refrain from posting in this thread.
I really don't know where you're getting that i'm unreliable?
Click to expand...

I didn't say any of those things.
 
thefiznut said:
What do you mean? Seriously, just be patient at read the above.
Click to expand...

This is the most random, single minded, uncalled for thread I have ever seen. If I left for five years and reappeared to type the equivalent of a short book in posts about the health benefits of sleeping in a hammock, it would be odd. You are odd.
 
It's not a short book, I wrote a lot because there is a lot of information about medicinal mushroom species. I started the thread to share my personal experience with them.
Just leave the thread if it serves no purpose for you. Please. I'm sorry you can't take the time to read long posts.
 
Sheepo said:
This is the most random, single minded, uncalled for thread I have ever seen. If I left for five years and reappeared to type the equivalent of a short book in posts about the health benefits of sleeping in a hammock, it would be odd. You are odd.
Click to expand...

Quit being a dick, Sheepo. This thread is a welcome change from the boring, usual cycle of gun, religion, and CptStern threads.
 
thefiznut said:
It's not a short book, I wrote a lot because there is a lot of information about medicinal mushroom species. I started the thread to share my personal experience with them.
Just leave the thread if it serves no purpose for you. Please. I'm sorry you can't take the time to read long posts.
Click to expand...

Why do you keep assuming we didn't read the damned thing? :/
 
Because people keep saying I am posting random links and babble that are unrelated, but they're all medical database references and cancer research institutions that consistently refer to the immunomodulatory action on immune system cells, and I listed them above. Would people rather me post a news.com article or something?

Clearly very few people read anything.


Its just irrititating to get this kind of response, even the "Housecleaning Reduces Cancer Risk" thread didn't get this many negative STFU responses.
I'm not lying, they have helped me transform myself and have alleviated suffering from my hereditary skin condition.
They have saved cancer patients lives, I promise you. And the on-going research being conducted globally is not a joke.The
They keep people from getting sick from bacteria fungus and viruses, thin blood, cause apoptosis in cancer cells and other pathogens, reduce tumors, reduce stress, lower bad cholesterol, and more.
I swear for the love of god, I am not lying and not pulling this out of my ass.

There are well-known institutions studying these things and for good reason.
http://en.wikipedia.org/wiki/Sloan_Kettering
This is one of many.. the former New York Cancer Hospital.
I even heard one of their researchers being interviewed on National Public Radio a couple mornings ago.
Why on earth would Sloan Kettering be suggesting on their website's database of alternative medicines that these mushrooms have the capability of alleviating cancers? Then post a large list of studies?
 
Gao Y, et al. Effects of Ganopoly ( Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-Stage Cancer Patients. Immunol Invest 2003;32(3): 201-15.
Thirty-four patients with advanced-stage cancer of various tissues were given 1800 mg of oral Ganopoly three times daily before meals for 12 weeks. Cytokines, T-cell subsets, and natural killer activity were measured to assess the effects of Ganopoly. Researchers found a significant increase in T-cell populations and NK activity at the 12-week period compared to baseline although the mechanism is unclear. More studies are needed to confirm these observations.
Click to expand...

Keep in mind Natural Killer cells are the most efficient attacking cell we have.

"Natural killer cells (or NK cells) are a type of cytotoxic lymphocyte that constitute a major component of the innate immune system. NK cells play a major role in the rejection of tumors and cells infected by viruses. They kill cells by releasing small cytoplasmic granules of proteins called perforin and granzyme that cause the target cell to die by apoptosis." - description of this cell copy/pasted from wiki.

The mechanism of action being witnessed by mushroom extract testing has always been apoptosis with regard to cancer cells.


And in regards to my claims about Agarikon anti-viral activity, Stamets and his research team have been conducting a study on Agarikon through this laboratory:
http://niaid-aacf.org/

It's an army owned anti-viral compound testing facility, and the Department of Defense are very interested in this mushroom with regards to their Project BioShield program, in testing substances for anti-viral activity against biochemical threats to the United States.
http://www.hhs.gov/aspr/barda/bioshield/index.html
This research is being funded by the NIH, the National Institute of Health, yes these people:
http://www.nih.gov/
our country's medical research agency...

That particular study will be published next year so wait for it and you will see.
So I guess everything I am posting about Paul Stamets is a joke right? Such a joke that even the DOD is hiring him for research..
He explains his work for them in his video above, segment four of the 6 ways mushrooms are important.
Considering he's been a biologist for 35 years it's highly unlikely he is lying.
 
And you're doing nothing but ad hominem attacking me while I am posting research for people to read.

Stop it please.
 
Medicinal mushroom Ganoderma lucidum is one of the most esteemed natural products that have been used in the traditional Chinese medicine. In this article, we demonstrate that G. lucidum triterpene extract (GLT) suppresses proliferation of human colon cancer cells HT-29 and inhibits tumor growth in a xenograft model of colon cancer. These effects of GLT are associated with the cell cycle arrest at G0/G1 and the induction of the programmed cell death Type II-autophagy in colon cancer cells. Here, we show that GLT induces formation of autophagic vacuoles and upregulates expression of Beclin-1 (1.3-fold increase) and LC-3 (7.3-fold increase) proteins in colon cancer cells and in tumors in a xenograft model (Beclin-1, 3.9-fold increase; LC-3, 1.9-fold increase). Autophagy is mediated through the inhibition of p38 mitogen-activated protein kinase (p38 MAPK) because p38 MAPK inhibitor, SB202190, induces autophagy and expression of Beclin-1 (1.2-fold increase) and LC-3 (7.4-fold increase), and GLT suppresses phosphorylation of p38 MAPK ( approximately 60% inhibition) in colon cancer cells. Taken together, our data demonstrate a novel mechanism responsible for the inhibition of colon cancer cells by G. lucidum and suggest GLT as natural product for the treatment of colon cancer.
Click to expand...

Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK).
Thyagarajan A, Jedinak A, Nguyen H, Terry C, Baldridge LA, Jiang J, Sliva D.

Methodist Research Institute, Indianapolis, Indiana, USA.
Lentinan, a beta-glucan nutritional supplement isolated from the shitake mushroom (Lentula edodes), is a biological response modifier with immunostimulatory properties. Concomitantly, the role of beta-glucans as chemoimmunotherapeutic in a number of solid cancers has been widely documented. We investigated the effects of nutritional grade lentinan upon BN rats and in a preclinical syngeneic model of acute myeloid leukemia. BN rats supplemented daily with lentinan exhibited weight gains, increased white blood cells, monocytes, and circulating cytotoxic T-cells; and had a reduction in anti-inflammatory cytokines IL-4, IL-10, and additionally IL-6. Lentinan treatment of BN rats with BNML leukemia resulted in improved cage-side health and reduced cachexia in the terminal stage of this aggressive disease. Combination of lentinan with standards of care in acute myeloid leukemia, idarubicin, and cytarabine increased average survival compared with monotherapy and reduced cachexia. These results indicate that nutritional supplementation of cancer patients with lentinan should be further investigated.
Click to expand...

Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia.
McCormack E, Skavland J, Mujic M, Bruserud Ø, Gjertsen BT.

Haukeland University Hospital, Bergen, Norway.

BACKGROUND: We previously reported that preoperative chemoradiotherapy (CRT) combined with intraoperative electron irradiation for cT3/T4 adenocarcinoma of the rectum reduced the local recurrence, with significant improvement of survival. Radiotherapy has been reported to reduce immune function. We examined the effects of PSK, a protein-bound polysaccharide, concomitant with preoperative CRT on immune responses. PATIENTS AND METHODS: Thirty patients with cT3/T4 adenocarcinoma of the rectum were randomly assigned to 2 weeks' irradiation and 4 weeks' S-1 administration before surgery (control group), or the same CRT with simultaneous 4 weeks' PSK administration (PSK group). Both systemic and local immune responses were evaluated. RESULTS: Significant increase of natural killer cell count in the peripheral blood and cytotoxic T-cell counts in the peri-tumoral and normal mucosa, and a significant decrease of serum immunosuppressive acidic protein level were observed in the PSK group. CONCLUSION: Combined use of PSK with preoperative CRT may improve immune function.
Click to expand...

Effects of preoperative immunochemoradiotherapy and chemoradiotherapy on immune responses in patients with rectal adenocarcinoma.
Sadahiro S, Suzuki T, Maeda Y, Tanaka A, Kamijo A, Murayama C, Nakayama Y, Akiba T.

Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. [email protected]



I'm begging you to please leave this thread, obviously you gain nothing from any of this, and if you are annoyed by my lengthy science posts then do yourself a favor and read other threads.
Your posts are every bit as uninformative and unnecessary.

My name is Zach Preston, I am from Virginia, USA, and I am trying to help people. How much more genuine can I get?
 
thefiznut said:
It's not a short book, I wrote a lot because there is a lot of information about medicinal mushroom species. I started the thread to share my personal experience with them.
Just leave the thread if it serves no purpose for you. Please. I'm sorry you can't take the time to read long posts.
Click to expand...
Okay, I mean it's fine, but you're the internet equivalent of a ranting homeless man in the street right now. Whether your information is correct, interesting, or valuable, you still sound crazy.
Danimal said:
Quit being a dick, Sheepo. This thread is a welcome change from the boring, usual cycle of gun, religion, and CptStern threads.
Click to expand...

Oh yeah, this thread is clearly leading to a lot of open discussion.

:eyeroll:

...

Where in my state do you live?
 
Well apparently medical scientists, oncologists, biologists, mycologists, etc feel otherwise.
If you're asking me where I live i'm in the Southwest of Virginia, feel free to meet me in person. For some reason I come across as a ranting homeless person online?
I'm quite not in real life.
 
Yeah, there is nothing alarming about the worship of fungi numbers, you're crazy.
 
Man, he reminds me of Kathaksung now. But Kathaksung had a point; he really was being watched.

edit:

Sheepo said:
Yeah, there is nothing alarming about the worship of fungi numbers, you're crazy.
Click to expand...

Lol.

ALL HAIL MUSHROOMS
 
This thread could have been really cool, but everyone had to go and shit on it. Way to go.

Now I'm off to go troll a LOLLOOKATTHISWEIRDNEWSSTORY thread.
 
Our pharmaceutical industry loves fungi, doesn't make sense why you wouldn't. Without fungi we wouldn't have ever had penicillin, as well as many other anti-viral drugs and medicines approved which are FDA approved and probably given to you many times by your doctor throughout your lifespan. Fungi were the first organisms to occupy our planet, and in large part responsible for the cyclical nature of destruction and regrowth of our Earth. Without fungi you would not eat bread. Every living plant around you in natural habitats depends on the symbiotic relationship between their roots and the hyphae of fungal mycelia. In their developmental cycle their roots search for mycorrhizial fungi and attempt to establish this relationship. Don't believe me, ask your local forestry department about this process. Fungi are molecular disassemblers who recycle life.
 
Whenever I accidentally eat a mushroom that sneaked past me on a pizza or sandwich, I want to throw up.
 
We get that, but there's no need to make such a fuss all



ALL HAIL FUNGI! ALL HAIL FUNGI! MY LIFE FOR THE FUNGI! MY LIFE FOR THE FUNGI!
 
I lost weight, started feeling more active, alert, stress-free, and rarely depressed after I started eating them in large doses.
My hereditary skin condition which wouldn't respond to any treatments by many doctors, dermatologists, and the University of Virginia dermatology department suddenly started improving slowly and steadily after introducing them.
I hardly get depressed anymore, neither does my roomate with clinical depression. He even told a friend that he feels a lot better, who later approached me in private and brought the subject up being curious.
I've somehow almost tripled my endurance and stamina in swimming and running working out for a mere three or four weeks.
In general I just feel a lot better about life and much, much more at ease.

So yeah, man. I guess I am pretty excited about these mushroom supplements i've been taking. Can you really blame me? It's kind of hard to not be fanatical when so much of my health has drastically changed for the better in a matter of two months total.. I had a friend yesterday tell me he hasn't seen me this lean and healthy looking since we've met.

What is so wrong with being excited about them? I don't understand you guys and your hatred for something that I started taking, experienced a drastic improvement in health, and have now found out that there's studies all over the planet showing an immumodulation response that improves the health of human beings, rats, or any eukarotic animal? I can't really believe it either, because it's really ****ing exciting to me that I ate them and felt the same too.. And supposedly asians did too and felt the same way about them as well..

Christ man, it's really hard to believe when I look in the mirror and feel good physical being for once in my life. It's been 15 years of suffering physically and within, and now I have the motivation to work towards my goals rather than shoot myself in the head? I've had suicidal thoughts sporatically for years, thankfully never trying too hard.. Sorry for being so ridiculously excited about not being in despair every day anymore, and having to force smiles all of the time.

http://fungi.com/supplements/medpics/other/testimonial.jpg

And hey animals dying from disease in a no-kill-shelter feel good again too.. Christ man, we're all just being fanatical watching dying animals spring back to life.
 
You guys are ****ing ridiculous. This is one of maybe four interesting threads in the first page of Off-Topic, and on a subject that I haven't seen come up directly in years in this forum. We could be discussing mycological history, or different antibiotic compounds, or even wasting space with some stupid jokes about tripping on shrooms or eating shiitake. And what happens? We shit all over this guy's actual scientific journal references and then have the gall to call him unbalanced.

Is it really that difficult to believe - hell, idly entertain - the notion that fungi can provide benefits to humans? Is it really so crazy to think that fungi have evolved some semblance of symbiotic relationships with the plant and animal species that they have co-existed with for literally billions of years? Obviously many of them are very toxic, but that comes with the territory of interacting with the deeper and more fundamental levels of a creature's biological operations. It's why fungi are so powerful, and why they can also give us some of the most powerful chemical defenses against things that are harmful to us.

Even if you still think the whole notion is crazy, the least you can do is not be a dick about what should be the most refreshing thread this forum has seen for years.
 
I agree. Even if you disagreed with his ideas, the least you could do is make an intelligent debate about it, instead of saying things like "you sound like a ranting homeless man".

Shameful.
 
thanks guys, thats all i was asking. i'm entirely open to debate as to why my health has improved or why these studies are bad science, but being called a zealot and just mocked the entire thread has really tainted how I feel about these forums..

i didn't know any of this and hadn't read a single study until after i had been taking them for a while, and when i couldn't explain why i kept feeling healthier only then did i find out that a lot of nations other than my own seem to have invested interest in them.
 
Stigmata said:
You guys are ****ing ridiculous. This is one of maybe four interesting threads in the first page of Off-Topic, and on a subject that I haven't seen come up directly in years in this forum. We could be discussing mycological history, or different antibiotic compounds, or even wasting space with some stupid jokes about tripping on shrooms or eating shiitake.
Click to expand...
No one's stopping you.
Wanted Bob said:
I agree. Even if you disagreed with his ideas, the least you could do is make an intelligent debate about it, instead of saying things like "you sound like a ranting homeless man".

Shameful.
Click to expand...

Well I'm not trying to argue against the medicinal effects of mushrooms, I'm really just pointing out that I think this random and huge amount of work put into the topic was pretty out there and that I find it's funny. If I had any real interest or knowledge on the subject that seemed more worth posting I probably would've posted that instead.
 
Sheepo said:
No one's stopping you.


Well I'm not trying to argue against the medicinal effects of mushrooms, I'm really just pointing out that I think this random and huge amount of work put into the topic was pretty out there and that I find it's funny. If I had any real interest or knowledge on the subject that seemed more worth posting I probably would've posted that instead.
Click to expand...

So what you're saying is that you don't care about the topic and you're only posting in this thread to make fun of the effort he's put into his posts?

Do you see how smart you sound? Great way to avoid infractions, man.
 
I wasn't trying to make fun of his efforts, I was merely trying to express how strange I found his sudden and fixed intensity on this particular subject (and if this were Danimal or Kathaksung or Stern this would probably be just fine, I'm not sure what's so special about this guy). Admittedly, it clearly sounded far worse to people than I intended and I had thought I'd put an apology somewhere in my last post but no yeah it's not there. I'm sorry if what I said sounded worse than I intended.
 
sheepofarkkyeah.jpg
 
thefiznut said:
thanks guys, thats all i was asking. i'm entirely open to debate as to why my health has improved or why these studies are bad science, but being called a zealot and just mocked the entire thread has really tainted how I feel about these forums..

i didn't know any of this and hadn't read a single study until after i had been taking them for a while, and when i couldn't explain why i kept feeling healthier only then did i find out that a lot of nations other than my own seem to have invested interest in them.
Click to expand...

Well, then, I suppose I owe you an apology. I just thought it was kinda funny that you were somewhat obsessed with mushrooms. :p

Tbh, I've never heard of medicinal mushrooms or mushroom supplements before. I dunno maybe I should try some, not in the best physical condition right now. Problem would be I wouldn't know where to get them.
 
15357 said:
Well, then, I suppose I owe you an apology. I just thought it was kinda funny that you were somewhat obsessed with mushrooms. :p

Tbh, I've never heard of medicinal mushrooms or mushroom supplements before. I dunno maybe I should try some, not in the best physical condition right now. Problem would be I wouldn't know where to get them.
Click to expand...

It's okay man. :)
Reading back through the thread I agree, supposing someone knew nothing about mushrooms and heard me rambling on about the immune system its hard to make the connection, but those Sloan Kettering pages I linked off the bat make it pretty easy to understand I think. If you're curious read through them and the wikipedia article as well. I've examined a bit and the information written on the wiki is a good overview of the current understanding of how they work according to the research done. It is true that our immune systems are all very similar in animals, a eukaryote framework. It's not always true that drugs that affect animal immune systems will affect humans. Although there's been a lot of animal model studies, the data has been pretty much the same in tests done using human immune systems - increase in cytokine, lymphocyte, T-helper, natural killer, interferon, phagocyte, macrophage, etc activity and increased production of these cells. I don't think it takes a scientist even to understand that the research is showing something special enough to be worth trying and I suggest that anyone should if they are struggling with health or degenerative disease .. are fungi trying to create a symbiotic link with higher eukaryotic organisms?

I started reading about NGF, or Nerve Growth Factor, last night out of boredom. If the studies showing strong NGF induction due to hericinones and erinacines are found true, this may be the biggest breakthrough humanity has ever seen when it comes to treating neurological disorders. Nerve Growth Factor is a protein that was discovered by neuroscientists Rita Levi-Montalcini and Stanley Cohen in 1986, and get this: their discovery and isolation won them the Nobel Peace Prize. Here's why:

http://en.wikipedia.org/wiki/Nerve_growth_factor

NGF is very important to the human nervous system, and is responsible for the growth, health, and longevity of nerve cells and in particular neurons. There's very compelling research suggesting that NGF has the capability of reversing diseases such as alzheimers and dementia, and that's exactly what a japanese lion's mane study with mild cognitively impaired adults suggested. Nearly every participant exhibited significant improvement in their neurological condition after 6 months of lion's mane intake.

Unfortunately NGF is difficult to receive into the brain, as the blood brain barrier, a cerebrospinal fluid defense from invading pathogens and microscopic particles, keeps NGF from passing through. NGF is too large to permeate. Typically in research NGF has been set by surgical procedueres, or in the case of Rita Levi who discovered it, shes been taking NGF eyedrops into her ocular-blood barrier daily for over four decades. She now reports at 100+ years of age that her brain works more efficiently than it did four years ago.

Imagine that. :) So I think i'll keep eating my lion's mane mushroom supplement...

00018431.jpg
 
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